Quantification of dark adaptation dynamics in retinitis pigmentosa using non‐linear regression analysis

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Quantification of dark adaptation dynamics in retinitis pigmentosa using non-linear regression analysis.

PURPOSE Non-linear regression analysis was used to determine dark adaptation indices in people with retinitis pigmentosa and in control subjects. METHODS Dark adaptation data were collected for 13 people with retinitis pigmentosa and 21 controls using the Goldmann-Weekers Dark Adaptometer. Data were analysed using an exponential non-linear regression model and dark adaptation indices derived....

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Pupil size following dark adaptation in patients with retinitis pigmentosa.

According to the equivalent light hypothesis, molecular defects in the photoreceptor lead to a continuous activation of the photoreceptor cascade in a manner equivalent to real light. The consequences in diseases such as retinitis pigmentosa (RP) are as disruptive to the cells as real light. Two forms of the equivalent light hypothesis can be distinguished: strong - mutations in rhodopsin or ot...

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The time course of dark adaptation was measured in 10 subjects from three families with autosomal dominant sector retinitis pigmentosa (RP) due to mutations in the first exon of the rod opsin gene. In each subject cone adaptation and the early part of the recovery of rod sensitivity followed the normal time course, but the later phase of rod adaptation was markedly prolonged. The recovery of ro...

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Light adaptation of the electroretinogram. Diminished in retinitis pigmentosa.

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ژورنال

عنوان ژورنال: Clinical and Experimental Optometry

سال: 2004

ISSN: 0816-4622,1444-0938

DOI: 10.1111/j.1444-0938.2004.tb03099.x